This article covers Cannabidiol, Serotonin, and CYP450 enzymes. It also discusses interactions with antidepressants. It is possible that CBD has a similar effect as SSRIs, but it is not clear how it differs from them. Let’s examine the different classes of antidepressants to learn more about their differences and similarities. Read on to find out.
Cannabidiol
Cannabidiol, a chemical found in cannabis, may work as an antidepressant faster than conventional medication. It induces sustained antidepressant-like effects in mice. According to the World Health Organization, depression affects more than 300 million people in the world and is the number one cause of disability. This substance may be the answer for those seeking a more natural treatment.
Serotonin
Researchers have recently found that a substance in cannabis, known as cannabidiol, induces an antidepressant-like effect in the brain. The study, published in Current Biology, was conducted by Amanda J. Sales, Carlos C. Crestani, Francisco S. Guimaraes, and Samia R.L. Joca. It was found that cannabidiol and serotonin interact to produce the same effect as conventional depression medications.
CYP450 enzymes
CYP450 enzymes are implicated in the primary metabolism of most xenobiotics and therapeutic agents. CBD interactions with CYP450 enzymes are also reported. The 3A4 isoform is responsible for the majority of CBD’s biotransformation. These enzymes also have many other functions, including inhibiting the enzymes responsible for metabolizing phenytoin and tylenol.
Interactions with antidepressants
While it is possible to take CBD in conjunction with any antidepressant, it is recommended that you start at a low dosage and increase it over time as your body adjusts to the effects of CBD. This way, you can monitor the changes in your mental state and body as you increase your dose of CBD. In addition, you can gradually reduce the strength of your antidepressants. However, if you take more than recommended, the dosage of CBD can cause serious side effects.
Side effects of consuming CBD and antidepressants
In a recent study, researchers found that a combination of antidepressants and CBD reduced the amount of anandamide in the brain, which improved mood and reactions to stressors. Interestingly, both compounds also increased the plasticity of the brain, affecting the hippocampus, which controls mood, emotions, and cognitive performance. As a result, CBD increased cognitive performance and decreased suicidal thoughts among depression patients. However, the findings have not been replicated in humans.
Article By:- Unbiased CBD Reviews